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4.8 Electrolytes (Potassium, Sodium) Physiological Role Electrolytes regulate: Fluid balance Cardiac conduction Neuromuscular function Why GLP-1 Therapy May Influence Electrolytes Electrolyte imbalance may occur secondary to: Persistent vomiting Diarrhoea Reduced fluid intake Rapid weight loss This is most relevant during dose escalation or in patients with ongoing GI symptoms

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Tirzepatide and semaglutide perform similarly in the first weeks, but tirzepatide pulls ahead in the later stages, reaching 20.2% average weight loss vs 13.7% for semaglutide over 72 weeks in head-to-head trial data