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However, patients should be counseled that severe vomiting or diarrhea (potential side effects when starting semaglutide) could potentially affect oral contraceptive absorption, as with any significant gastrointestinal illness

Researchers confirmed this through knockout studies in mice, where animals lacking beta-3 adrenergic receptors showed zero response to AOD 9604, proving the peptide works specifically through this receptor pathway in adipose tissue

Instruct patients to immediately inform their healthcare provider at the first appearance of skin rash [see Warnings and Precautions (5.14)]