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Sympathetic activation was evident, with higher plasma norepinephrine levels and increased FosB expressiona marker of sustained neuronal excitationin the parvocellular paraventricular nucleus and the rostral ventrolateral medulla

Semaglutide can also improve heart failure-related symptoms and inflammation in patients with obesity-related heart failure with preserved ejection fraction (HFpEP), and decrease the risk of major kidney disease events and cardiovascular-related mortality in patients with type 2 diabetes and chronic kidney disease(Butler et al 2024

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