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By 8 mg, the weight-loss curve has reached about 94% of the 12 mg result because the downstream response approaches its ceiling before receptor occupancy does. None of those occupancy numbers are fixed, though
This is crucial for anyone on Metformin, PPIs (acid reflux meds), or those who have had gastric bypass surgery
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Neurological symptoms such as tingling or numbness are more commonly associated with B12 deficiency rather than excess and warrant medical assessment
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