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Efficacy and safety of once-weekly semaglutide versus once-daily insulin glargine as add-on to metformin (with or without sulfonylureas) in insulin-naive patients with type 2 diabetes (SUSTAIN 4): a randomised, open-label, parallel-group, multicentre, multinational, phase 3a trial

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The structure represents the covalent acyl-enzyme intermediate, which cannot be resolved by a water molecule as nucleophile in this case (Supplementary Fig

McCall McPhereson: Yeah, I mean, Honestly, I don't want to oversimplify it, but kind of the same way that you prevent it in regular life too, right