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Addressing these and other vital clinical questions will require additional investment in basic, translational, clinical and implementation research. They conclude: The management of hyperglycaemia in type 2 diabetes has become extraordinarily complex with the number of glucose-lowering medications now available

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Smaller water volumes yield higher concentrations, allowing smaller injection volumesuseful in studies where injection site volume limits apply

Crucially, because it avoids insulin signalling pathways, it does not change blood glucose levels