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Semaglutide acts like a gut hormone signal, while metformin mainly reduces liver glucose output and improves insulin sensitivity

Abstract Parkinsons disease (PD), the second most common neurodegenerative disorder worldwide, features gradual loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) along with pathological -synuclein (-syn) aggregation

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The first results from tests show that these dual agonists may lower blood glucose levels and body weight more effectively than GLP-1 agonists on their own, especially when used in higher doses