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Here, we report the design of a promising class of FAK scaffold inhibitors, all-hydrocarbon-stapled peptides based on the paxillin LD2 alpha-helical motif, that target the FAT-paxillin interaction
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Discontinuation due to side effects ran at 7% in Phase 2 data, which is lower than Semaglutides 11% discontinuation rate despite Semaglutide having a higher reported nausea incidence at 44%
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