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Up to 25% body weight loss The SURMOUNT clinical trials demonstrated that tirzepatide therapy not only improved glucose levels but also had a substantial impact on body weight reduction
The equivalence margin ( 2 percentage points) was selected as a pragmatic threshold for between-treatment differences, rather than an absolute clinical target
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Patients with cardiovascular disease, chronic kidney disease, or other obesity-related complications may benefit from extended treatment, though cardiovascular and renal outcome trials with tirzepatide are still ongoing, and definitive risk reduction benefits remain under investigation
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