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Hemolysis is especially problematic in plasma or serum because erythrocytes contain much larger glutathione pools (Tomin et al., 2020
This study followed a cohort of more than 800 participants over a 20-year period and found that individuals with higher dietary spermidine intake had a significantly lower risk of death from all causes, including cardiovascular disease and cancer
The social pressure for lighter skin in parts of Asia has even led to public health messages against overzealous skin bleaching
However, substantial heterogeneity among studies was observed, likely attributable to differences in dosage, baseline B12 status, and population characteristics
