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For detoxification or immune support, weekly or twice-weekly sessions are often recommended during the initial four to six weeks

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Am J Hypertens 32:695702

Melatonin also activates antioxidative enzymes like glutathione peroxidase, glutathione reductase, superoxide dismutase, and glucose-6-phosphate dehydrogenase to prevent cellular damage that can occur during periods of oxidative stress