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Estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers
ROS are highly reactive radical and non-radical forms of oxygen comprising superoxide anion (O 2 ), hydrogen peroxide (H 2 O 2 ), and highly reactive hydroxyl (OH) groups that are produced during oxygen metabolism during photosynthesis, oxidative phosphorylation, and peroxisomal activity 10,11
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