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Other conditions that have been associated with MetS are strongly related with insulin resistance and adiposity, namely, non-alcoholic fatty liver disease (NAFLD), polycystic ovarian syndrome, obstructive sleep apnoea (OSA), hypogonadism, lipodystrophy, and microvascular disease

Both peptides are also contraindicated in subjects with a history of thyroid cancer based on increased risk observed in rat studies, although such concerns have not been confirmed in human trials [40]

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