semaglutide metallic taste in mouth Ozempic tongue explained 👅 If food suddenly tastes metallic, bitter, or just off while taking Ozempic, Wegovy, Mounjaro, or other GLP-1 medications… you're not alone. 'Ozempic tongue' isn't a medical diagnosis, but Dry Mouth Relief for GLP-1

What they found: Oral AOD-9604 reduced body fat by 18 to 22 % vs placebo, comparable to injection administration No changes in total body weight (because lean mass rose slightly) Decrease in plasma triglycerides by 30 % Decrease in resting free fatty acids (paradoxically, mobilization of fat from depots into oxidation) No GI side effects Why it matters: It suggested that AOD-9604 could work orally , a rare property for a peptide

For patients who have had their gallbladder removed, this slower digestion may reduce the urgency of bile flow into the intestine, potentially easing some post-surgical digestive symptoms

20 February 2024

In plain terms, Lilly posits that selectively targeting AMY1 reduces food intake & body weight with less taste avoidance (aka food still tastes good!) with less GI side effects that seem to be driven by the non-selective activity of cagrilintide on all these receptors