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Furthermore, the cohort consisted primarily of Caucasian participants which would limit its generalizability
Without it, RBC precursors grow abnormally large (megaloblasts) and fail to mature
Because nicotinamide would otherwise re-enter the NAD+ salvage pathway through NAMPT and NMN, NNMT activity sits at a junction between cellular methylation capacity and NAD+ regeneration, which is why the enzyme became a target after Kraus and colleagues (Nature, 2014) reported the consequences of antisense Nnmt knockdown in white adipose tissue and liver
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