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GHK-Cu and Skin Biology Research In vitro studies with human adult dermal fibroblasts found that GHK-Cu at concentrations of 0.01, 1, and 100 nM increased production of both elastin and collagen, with all concentrations increasing TIMP1 a key inhibitor of matrix metalloproteinases
Muscle mass preservation is an important consideration given the risk of sarcopenic obesity: weight loss with GLP-1 RAs includes a lean mass component (approximately 25%-40% of total weight loss), though the clinical significance in MASLD patients without sarcopenia is uncertain
Some cancers (particularly those with IGF-1 receptor expression) may warrant caution even after remission Diabetic retinopathy: GH can worsen proliferative retinopathy Pregnancy/breastfeeding: Safety not established Uncontrolled diabetes: GH can temporarily worsen blood sugar control
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