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Common gastrointestinal side effects: The most frequently reported adverse effects are gastrointestinal in nature, occurring in up to 40-80% of patients with higher doses, particularly during dose escalation: [13] [14] Nausea (most common, typically improves after 4-8 weeks) Vomiting Diarrhoea or constipation Abdominal discomfort or bloating Reduced appetite These effects can be minimised by starting with low doses and gradually titrating upwards according to manufacturer guidance

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