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This disparity largely stems from Semaglutide being a prescription medication, which requires manufacturing under stringent conditions and rigorous clinical testing for efficacy and safety, contributing to its higher price point
Variants in GIPR (the GIP receptor particularly relevant for tirzepatide given its dual GIP/GLP-1 mechanism), FTO (appetite regulation), MC4R (satiety signaling), and TCF7L2 (insulin response) are associated with measurably different response patterns to semaglutide and tirzepatide
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