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NIT-1 cells treated with PA + Ex-4 and PA + GW showed enhanced GSIS capacity, increased PPAR expression, decreased UCP2 expression and ADP/ATP ratio, and improved mitochondrial DNA content and mitochondrial membrane potential compared with those treated with PA alone, whereas the opposite results were observed in the PA + GSK group
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Once oxidized during ROS detoxification (most notably through glutathione peroxidasemediated reduction of hydrogen peroxide), glutathione must be regenerated from its oxidized form (GSSG) by glutathione reductase, a process dependent on a continuous supply of NADPH from the pentose phosphate pathway (3)
Importantly, the reduction in LBM was modest relative to the overall BW loss, suggesting that GLP-1 RAs favor selective adipose tissue reduction over loss of lean tissue
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