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Most patients experience peak diarrhea symptoms during weeks 3 to 8 of treatment, with significant improvement by week 12 as their gut adapts to the medication
Months 6 to 12: The SURMOUNT-5 trial published in the NEJM in 2025 found tirzepatide produced 20.2% body weight loss compared to 13.7% for semaglutide over 72 weeks in patients with obesity
But for those using GLP-1s for weight loss or weight management alone, pregnancy is not the time to begin or resume one
Rhonda Patrick: And when I exercise, it's funny because I'm a female, and you think that I'd be exercising to stay fit, and in shape, and care about my figure
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