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We have therefore necessarily made a number of assumptions about the loss of GSH, GSSG, Cys, Gly, and Glu to other tissues

our data showed that these compounds were effective considering the latency time of the mice and that 3-hydroxytyrosol showed the highest antiamnesic effect

Many preclinical studies have demonstrated that the expression of key enzymes for GSH synthesis (GCL, SLC7A11, GS) and GSSG reduction-related enzymes (G6PD, NADPH, and GR) is downregulated in myocardium exposed to pathological factors [40, 43,44,45,46,47,48,49,50]

For example, it is known that GH and nutrition are the major factors that regulate hepatic IGF-I expression, as well as in other organs[24, 25]