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Among these are insulin resistance, elevated levels of low-density lipoprotein (LDL) cholesterol and hyperuricemia, which is an excessive buildup of uric acid
Its drug Imcivree (setmelanotide) has been approved by the FDA for three rare genetic diseases that cause obesity and is currently seeking approval for Hypothalamic Obesity (obesity due to genetic or physical damage to the hypothalamus)
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On the other hand, 22 metabolic pathways were significantly downregulated in GDH3 -deleted cells cultured in MM medium and only oxidative phosphorylation, sulphur metabolism, biotin metabolism, pyrimidine metabolism, and glycolysis/gluconeogenesis were upregulated
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