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This digestive adjustment is often more noticeable when starting treatment or after a dose increase and may improve over time

At C$145.00 for 10mg total, the per-mg math is straightforward: CagriSema blend at C$145.00 / 10mg = C$14.50 per mg of total peptide That C$14.50/mg figure is what should be compared across suppliers (not the per-vial price), and it's also the right number to use when comparing CagriSema to the single-component GLP-1 peptides: CagriSema is at the higher end of the per-mg range, which makes mechanistic sense: it's a two-component product, and cagrilintide is a more complex peptide than semaglutide

Potential risks and safety concerns The theoretical benefits of this combination come with substantial unknowns

The 48-week trial focused on people with obesity or overweight, but not those with type 2 diabetes