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Hispidulin is effective in inhibiting c-fos and major MAPKs (ERK1/2, p38, JNK), thereby reducing microglial activation and the production of pro-inflammatory cytokines, consequently diminishing seizures and hippocampal inflammation ( Beyond the aforementioned signaling pathways, flavonoids play a significant role in epilepsy treatment by modulating enzyme activities and influencing other signaling pathways

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