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In addition, treatment of rhabdomyosarcoma cells with anti-IGF-IR mAb or IGF-IR/IR kinase inhibitor leads to increased activation of YES/Src family tyrosine kinase (SFK) [173]
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Commenting on the study, Hannah Beba, clinical lead for obesity at the West Yorkshire Health and Care Partnership, called the retatrutide topline results genuinely striking, noting that the 30% weight loss was a level long associated with bariatric surgery
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