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Among them, TPZP stood out, delivering approximately 20-fold higher cytotoxicity under hypoxia with a similar selectivity ratio
In the Phase II SYNERGY-NASH trial, up to 62% of tirzepatide recipients achieved MASH resolution without worsening of fibrosis, versus 10% in the placebo group, while up to 55% saw improvement of at least one fibrosis stage without worsening of MASH, versus 30% of placebo recipients
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