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If your fasting or post-meal glucose jumps by 2030 mg/dL (1.11.7 mmol/L), or your usual weight loss stalls even with correct dosing, the drug mightve lost potency
Response depends on adherence, baseline metabolism, and biological factors including genetic architecture in appetite and energy regulation genes
Radtke MD, Pitts SJ, Jahns L, Firnhaber G, Loofbourrow BM, Zeng A, et al
Heres what to actually watch for: Common (usually mild): Mild nausea, especially in the first 48 hours after injection Reduced appetite (this is the goal, but can go too far) Fatigue during the first two weeks Constipation or occasional loose stools Injection site irritation Less common but real: Hair thinning, usually tied to rapid weight loss rather than the drug itself Muscle loss if protein intake drops Gallbladder issues in patients with pre-existing risk Mood shifts (both directions have been reported) Serious (rare but require attention): Pancreatitis Severe dehydration Allergic reactions to the compounded formulation Is microdosing semaglutide safe
