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Senescent keratinocytes die by autophagic programmed cell death
To activate Cre recombinase and induce Gclc deletion in tumour pieces from Gclc f/f Rosa26 creERT2 MMTV-PYMT mice, female mice were intraperitoneally injected with tamoxifen (Sigma-Aldrich, T5648) at 50160 mg kg 1 once daily for 5 consecutive days
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Glutathione competitively inhibits melanin synthesis in the reaction of tyrosinase and L-DOPA by interrupting L-DOPAs ability to bind to tyrosinase during melanin synthesis
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