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Yet, one study in 24 healthy volunteers reported no significant drug interactions with the co-administration of a single oral dose of lipoic acid (600 mg) and the oral anti-diabetic agents, glyburide (also called glybenclamide) or acarbose (Precose/Prandase/Glucobay) (119)
Behind this phenomenon is the deep intervention of GLP-1 in the "central plan" of cellular energy metabolism: it activates GLP-1 receptors, reprograms cellular energy distribution pathways, and shifts the body from an "energy wasting" metabolic mode to an "efficient and economical" one, thereby achieving the dual goals of disease treatment and health improvement
Research has demonstrated its involvement in wound healing through enhanced collagen and decorin gene expression [1] , activation of tissue remodeling pathways [2] , and regulation of genes associated with antioxidant defense and anti-inflammatory responses [3] [4]
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