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Transepithelial transport can occur by energy-independent direct uptake or paracellular diffusion, and by energy-dependent endocytic pathways and transcytosis, receptor-aided transport, or carrier-medicated translocation ( FIGURE 1 Transcellular transport mediated by either passive diffusion or active transport is a cellular process primarily used for the transport of lipophilic molecules ( via transcytosis, avoiding lysosomal degradation ( Among the passage routes of drugs via nasal mucosa, large molecules like peptides, proteins, and nucleic acids are often reported to cross the nasal epithelium following the transcellular pathway or endocytosis ( via the paracellular pathway through intercellular tight junctions ( 3.3 Challenges of CPP-mediated nasal drug delivery Although CPP-driven nasal delivery is regarded as a promising tool in facilitating non-injectable delivery of drugs, there are some challenges

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