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Study Design Two groups of adult dogs 1 year old or older (n=6 each for canine studies 1 and 2) from a commercial research facility were enrolled in the studies

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511 However, most of the Tau protein-targeting therapies tested to date have been immunotherapies that can target Tau proteins intracellularly and/or extracellularly, but targeting extracellularly alone is unlikely to be effective, 512 and no Tau-targeting therapies have yet to show definitive clinical efficacy in preclinical or early-stage AD

Nevertheless, our results suggest that nausea is the only significant adverse effect in patients on medication, reported twice as much in cases undergoing treatment