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This, in turn, activates the protein kinase A (PKA), which induces a cascade of phosphorylation and activation of the transcription factor CREB [32]
doi: 10.1007/BF03343763 253 TakayaKAriyasuHKanamotoNIwakuraHYoshimotoAHaradaMet al
This neurodegeneration is accompanied by the formation of characteristic Lewy bodies, which are intracellular inclusions composed largely of aggregated and misfolded -synuclein ( This degeneration of dopaminergic neurons is strongly linked to the generation of reactive oxygen species and oxidative stress as well as mitochondrial dysfunction, neuroinflammation, and aging (Smeyne and Smeyne, 2013)
Active chemotherapy requires careful timing and medical supervision
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