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However, different from the predicted binding mode of ghrelin, all the peptide moiety of ghrelin occupies the large cavity I while the octanoyl moiety attached to Ser3 of ghrelin extends into the small cavity II in the structure of ghrelin-bound GHSR (Fig
GHRP class research has identified four synthetic hexapeptide and pentapeptide compounds GHRP-2, GHRP-6, hexarelin, and ipamorelin that stimulate growth hormone release through the ghrelin receptor (GHS-R1a), each with a distinct pharmacological profile that guides their selection in published preclinical and clinical protocols
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These messengers, in turn, may activate protein kinases that phosphorylate transcriptional regulators, potentially modulating GH-related gene expression within the nucleus
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