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Upregulation of MAPK/MCL-1 Maintaining Mitochondrial Oxidative Phosphorylation Confers Acquired Resistance to BCL-2 Inhibitor Venetoclax in AML

It also plays a crucial role in recycling other antioxidants like vitamins C and E, maintaining immune balance, and promoting healthy aging by reducing the impact of environmental and metabolic stressors on the body

Modern life in this city long working weeks, year-round sun exposure, frequent travel, intense training, sleep disruption and chronic background stress generates a sustained load of oxidative stress that the body's antioxidant systems were never designed to manage on their own

These differences cause ER to have opposite effects on proliferation, apoptosis and migration with some reports suggesting that ER activation is antagonistic to ER 13,14