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In practice, this means: No persistent nausea or vomiting for at least 7 consecutive days at the end of the current phase No ongoing diarrhea or significant GI discomfort that impacts daily functioning You are in week 4 or later at the current dose level (the 4-week minimum is absolute) If any of those conditions are not met at week 4, you are not ready to escalate
Domnguez-Oliva A, Mota-Rojas D, Semendric I, Whittaker AL
The FOT represents the relative abundance of each GP
Yes, the order in which products are applied is important
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