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Mechanisms of IGF-1Mediated Regulation in Skeletal Muscle

Oxidative stress occurs when there is an imbalance between free radicalsunstable molecules that can damage cellsand the antioxidants that neutralize them

Method Literature search strategy Google Scholar and PubMed were searched on various dates between December 2016 and March 2017, ending on 15th March 2017 using the following terms, and variants thereof, and all articles discovered were considered for inclusion: (paracetamol OR acetaminophen hepatotoxicity) AND genetic differences/polymorphisms OR children/neonates/young people/paediatric OR older people/elderly/geriatric OR nutritional state/malnutrition OR body weight/low body weight OR alcohol/alcohol-dependence OR drug interactions/potentiation OR liver disease/chronic liver disease/liver failure

All the SOD polymorphisms investigated by the authors have been reported in Table 1, but only the most significant have been discussed here