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Patients on this protocol who also use metabolic support agents like Metformin should note that both agents activate AMPK, and physician oversight is warranted to avoid compounding effects on blood glucose that could theoretically cause hypoglycemia in susceptible individuals, though this has not been reported clinically with MOTS-c at standard doses

As of 2026, DSIP is not approved by any regulatory authority (FDA, EMA, ANSM)

Dihexa is a modified hexanoic acid-Tyr-Ile dipeptide derived from angiotensin IV, developed at Washington State University as an ultra-potent cognitive enhancer