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Animal studies show IGF-1 LR3 can cause organ growth and changes in insulin and blood sugar levels
Cardiovascular data on endpoints like MACE-3 or MACE-4 are presently not available yet, but an early meta-analysis demonstrated at least cardiovascular safety in patients with T2D treated with tirzepatide (78, 79)
119,120 To improve bioavailability and maximize therapeutic potential, a phase II clinical trial in which naked mRNA encoding VEGF-A was injected into the human heart was conducted
The dosing is gradually increased over time to reduce the chance of gastrointestinal discomfort, which is common during early weeks of treatment
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