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Vitamin K2 induces mitochondria-related apoptosis in human bladder cancer cells via ROS and JNK/p38 MAPK signal pathways

Absorption rate: Though slower than IV and IM, absorption rate still performs well over time

Phase I reactions (primarily oxidation, reduction, and hydrolysis) structurally modify the parent compound but frequently generate reactive intermediates that can be more cytotoxic than the original molecules

Additionally, ROS can promote the recruitment and activation of immunosuppressive cells, such as regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), which further inhibit the anti-tumor immune response and facilitate tumor progression [123]