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Our review provides insights into the relevant regulatory mechanisms of ferroptosis, examining the impact of ferroptosis-related factors from both physiological and pathological perspectives
Despite the role of methionine synthase in the synthesis of methionine from homocysteine, the major function of methionine synthase, under normal physiological conditions, is in the recycling of of tetrahydrofolate (THF) and not in the synthesis of methionine
Complementary, the high tumor accumulation was confirmed upon determination of the metal content in the respective organs by ICP-MS
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