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The main cause of vitamin B12 or folate deficiency is poor dietary intake of the vitamin (not taking adequate levels of the vitamins from food)
Clinical trials measuring body composition found that fat mass reduction occurred without corresponding increases in lean tissue mass, confirming the absence of anabolic muscle-building effects
24 Table 3 Estimated Sensitivity and Specificity of Serum Laboratory Tests for Vitamin B12 Deficiency Pernicious anemia refers to one of the hematologic manifestations of chronic auto-immune gastritis, in which the immune system targets the parietal cells of the stomach or intrinsic factor itself, leading to decreased absorption of vitamin B 12
In the studied context, a review of six clinical trials found a safety profile comparable to placebo, without the IGF-1 effects of full growth hormone
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