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This is the dominant satiety pathway shared with semaglutide and tirzepatide
Senolytic therapies may be an effective approach for preventing cancer recurrence and therapy resistance
Yet another strategy is to use a molecular degrader of extracellular proteins, which links a target-binding unit (for instance binding to IgG, as with BHV-1300 [418]) to a motif that binds asialoglycoprotein receptors (ASGPR) to direct its targets to endolysosomal degradation in the liver [419, 420]
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