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Participants were not allowed to take any other supplements except a standard optional multivitamin offered by the trial team

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However, at higher than physiologic pH levels, the stimulation of hexokinase and phosphofructokinase activity merely results in the accumulation of fructose diphosphate and triosephosphates, because the availability of nicotinamide adenine dinucleotide (NAD) + for the glyceraldehyde phosphate dehydrogenase (GAPDH) reaction becomes a limiting factor