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What the Researchers Found Compared with the information control, the combined feedback and text-message group reported greater reductions at three months (incidence rate ratio 0.34) and six months (incidence rate ratio 0.40).The feedback-only group showed a significant reduction at six months compared with control (incidence rate ratio 0.25)

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Together, these three mechanisms, coordinated neuronal energy support, reduced neuroinflammation, and complementary synaptic maintenance, make the combination of HRT and GLP-1 receptor agonists particularly relevant for the preservation of cognitive resilience during the menopausal transition and beyond