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Research shows leucine alone causes substantial depletion of the other BCAAs from muscle tissue, ultimately limiting protein synthesis despite strong initial signaling
Centrally, GLP-1 receptor activation in the hypothalamus and brainstem suppresses appetite and reduces food intake
Experimental evidence indicates curcumin safely mitigates these effects, reducing cisplatin-induced anxiety and depressive behaviors (Mohammad Abu-Taweel and Al-Fifi, 2021)