Available from: Accessed 1 Mar 2023 Brown E, Heerspink HJL, Cuthbertson DJ, Wilding JPH (2021) SGLT2 inhibitors and GLP-1 receptor agonists: established and emerging indications
Dietary considerations may play a supportive role, although these are not proven to prevent gallstones in GLP-1 users: Maintain regular meal patterns rather than severely restricting calories, which helps stimulate regular gallbladder contraction Include moderate amounts of healthy fats in the diet (such as olive oil, nuts, and oily fish) to promote gallbladder emptying Ensure adequate hydration to support bile flow Avoid very low-calorie diets unless under specialist supervision For individuals at particularly high risksuch as those with a history of gallstones, rapid weight loss, or multiple risk factorssome specialists may consider ursodeoxycholic acid (UDCA) prophylaxis
Research suggests this coordinated signaling can produce more consistent GH pulses, enhance the precision of GH-related assays, and provide a broader view of metabolic, lipolytic, and regenerative mechanisms than either compound individually
Both males and females in regions like Eastern Sub-Saharan Africa, East Asia, and Southeast Asia exhibit high DALYs values, with males significantly surpassing females
