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However, this increase in demand has had an impact on overall pharmacy spending, making it essential for employers to pay attention to how these drugs affect their health care costs

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Similar results were obtained in the experiment using H 2 O 2 .Citation 77 ) Moreover, marked decreases in ischemia damage are found in in vivo rat models, such as cardiovascularCitation 78,79 ) or cerebral ischemia models.Citation 80,81 ) The underlying mechanisms elucidated were that PQQ acts as an anti-oxidant by scavenging and protects mitochondria from oxidative stress-induced damage.Citation 58 ) In humans, following a single dose of PQQ Na 2 (0.2 mg/kg body weight), thiobarbituric acid reactive products (TBARS), which are measured by the malondialdehyde generated from lipid hydroperoxides, significantly decreased over the time course of the study.Citation 28 ) In addition, the change of TBARS values correlated significantly with the maximum plasma concentration ( C max ) for PQQ Na 2

While clinical interactions have not been documented, combining multiple compounds that affect similar pathways increases unpredictability