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Common Reasons Weight May Increase During Treatment Short-term weight increases during retatrutide treatment are most often caused by normal daily fluctuation, fluid retention, constipation, or inadequate appetite suppression during early dose titration rather than treatment failure

The SURMOUNT-5 head-to-head trial confirmed statistically significantly greater weight reduction with tirzepatide at comparable doses

The brains reward system plays a key role in both eating behavior and substance use