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Glycosylation plays a crucial role in cellular stress responses and signaling is closely linked to the regulation of NRF2
This also results in an improvement in facial symmetry
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Starting from one of the first studies on this topic, it has been demonstrated that missense mutations on codon 132 in IDH1 gene are present in different tumor types diverse than glioblastoma multiforme or gliomas, including prostate carcinomas [43], opening the way to the investigation of the role of 2-HG also in this tumor type
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