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FEBS Letters 238(2):343-346. [doi.org]
showed that the DOX-processing myocardium exhibited features of typical ferroptosis in mice
It is a tightly regulated reaction that depends on both the availability of the amino acids (cysteine, glycine, and glutamate) and the rate-limiting enzyme, glutamate-cysteine ligase ( GCL )
In clinical use, significant side effects are uncommon, and the vast majority of patients tolerate the therapy without problems
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